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The Surprising Health Benefits of GLP-1 Weight Loss Drugs
The GLP-1 appetite suppression mechanism works by signaling the brain’s satiety centers to reduce hunger and increase feelings of fullness
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Failure Mode 6: True pharmacological resistance True non-response to tirzepatide, where the medication never produces meaningful weight loss despite adequate dosing and adherence, affects 2-3% of patients in clinical trials (Jastreboff et al., NEJM 2022)